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Phenergan (promethazine) is an antihistamine used to relieve symptoms of allergies, including rash, itching, runny nose, and sneezing. It is also effective for preventing and treating nausea, vomiting, and dizziness caused by motion sickness or anesthesia. Phenergan can be used as a sedative or sleep aid before or after surgery. It works by blocking histamine and affecting certain chemical signals in the brain responsible for nausea and allergic reactions.
Phenergan is available in tablets, suppositories, and injectable forms. The typical oral dose for allergies or motion sickness in adults is 25 mg once daily or in divided doses. For nausea or vomiting, 12.5–25 mg every 4–6 hours as needed is common. Dosage for children depends on age and condition and should be determined by a physician. Take the medication exactly as prescribed. Do not crush or chew tablets. If used for motion sickness, take the dose 30–60 minutes before travel for best results.
Phenergan may cause drowsiness, dizziness, or blurred vision. Avoid driving or using heavy machinery until you know how it affects you. Inform your doctor if you have respiratory issues, glaucoma, liver disease, heart conditions, epilepsy, or sleep apnea. Children and elderly patients are more sensitive to side effects such as respiratory depression and confusion. Do not consume alcohol or other CNS depressants while taking Phenergan, as they may intensify sedative effects. Sun exposure should be limited, as Phenergan can increase sensitivity to sunlight.
Do not use Phenergan if you are allergic to promethazine or similar antihistamines. It is contraindicated in children under 2 years old due to the risk of fatal respiratory depression. It should not be used in comatose patients or those taking MAO inhibitors. Patients with severe breathing problems or a history of seizures should use this medication only under strict medical supervision.
Common side effects include drowsiness, dry mouth, dizziness, constipation, and blurred vision. Less frequent but more serious effects may include irregular heartbeat, confusion, hallucinations, fainting, and uncontrollable movements. Rarely, Phenergan can cause neuroleptic malignant syndrome or severe allergic reactions. Seek immediate medical help if you experience difficulty breathing, swelling, or high fever with muscle stiffness.
Phenergan can interact with other drugs that cause drowsiness such as sleeping pills, muscle relaxants, opioid pain medications, and antipsychotics. It may also affect the action of seizure medications, blood pressure drugs, or antidepressants. Avoid using with MAO inhibitors or within 14 days of stopping one. Always inform your healthcare provider of all medications and supplements you are taking.
If you miss a dose of Phenergan, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one. Do not double your dose to catch up. For motion sickness or nausea, it is important to take doses on time for consistent relief.
Symptoms of overdose may include severe drowsiness, confusion, agitation, hallucinations, shallow breathing, and fainting. In children, overdose may cause excitability followed by drowsiness. If overdose is suspected, seek emergency medical help immediately. Treatment may include activated charcoal, respiratory support, and monitoring of vital signs.
Store Phenergan at room temperature between 15°C and 30°C (59°F and 86°F). Protect from moisture, heat, and light. Keep out of reach of children and pets. Do not store in the bathroom. Properly dispose of unused or expired medication in accordance with local pharmacy or waste disposal regulations.
Phenergan is legally available through The Urological Institute of Northeastern New York, a certified and licensed online pharmacy offering trusted access to antihistamine therapy for allergy and nausea management across the United States.