Indocin (Indomethacin) is a prescription NSAID used to relieve pain and inflammation caused by a variety of musculoskeletal conditions. It is particularly effective for treating osteoarthritis, rheumatoid arthritis, gouty arthritis, ankylosing spondylitis, bursitis, and tendinitis. Indocin works by blocking the production of prostaglandins, substances in the body responsible for causing pain and inflammation. It is commonly used in both acute and chronic conditions and may be prescribed in immediate or extended-release form depending on the patient's needs.
Indocin is usually taken by mouth 2 to 3 times a day with food, milk, or an antacid to reduce stomach upset. The starting dose may range from 25 mg to 50 mg per dose, and the daily maximum is generally capped at 200 mg unless directed otherwise by a doctor. For chronic conditions, extended-release tablets may be taken once or twice daily. Your doctor will determine the appropriate dose based on your condition, response to treatment, and risk of side effects. Do not crush or chew extended-release forms of the medication.
Before using Indocin, inform your doctor if you have a history of stomach ulcers, bleeding disorders, liver or kidney disease, high blood pressure, heart conditions, or asthma. This medication may increase the risk of serious cardiovascular events or gastrointestinal bleeding, especially with prolonged use. Avoid alcohol and smoking while taking Indocin, as these can worsen stomach irritation and bleeding risk. Indocin may cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you. Periodic lab tests may be required to monitor liver, kidney, and blood parameters.
Indocin is contraindicated in individuals with known hypersensitivity to Indomethacin or other NSAIDs. It should not be used in patients with active gastrointestinal bleeding, a history of NSAID-induced asthma, or recent coronary artery bypass graft surgery. Use during pregnancy, especially in the third trimester, is not advised unless absolutely necessary. Always inform your healthcare provider of your full medical history before beginning treatment with Indocin.
Common side effects of Indocin include headache, dizziness, nausea, vomiting, diarrhea, and stomach pain. More serious effects may include high blood pressure, fluid retention, vision changes, mental/mood changes (such as depression), easy bruising or bleeding, signs of kidney problems, or allergic reactions like rash, itching, and trouble breathing. Seek medical help immediately if you experience chest pain, slurred speech, black or bloody stools, or severe stomach pain.
Indocin can interact with other medications including blood thinners (like warfarin), other NSAIDs, corticosteroids, lithium, ACE inhibitors, diuretics, SSRIs, and methotrexate. These interactions may increase the risk of gastrointestinal bleeding, kidney problems, or drug toxicity. Be sure to inform your doctor of all prescription, over-the-counter medications, and supplements you are currently taking to avoid harmful interactions.
If you miss a dose of Indocin, take it as soon as you remember. If it is close to the time for your next dose, skip the missed one and resume your regular schedule. Do not double your dose to catch up. Taking more than prescribed can increase the risk of side effects, particularly gastrointestinal and cardiovascular complications.
Symptoms of Indocin overdose may include severe headache, confusion, nausea, vomiting, drowsiness, and even seizures or loss of consciousness in extreme cases. If overdose is suspected, seek emergency medical help immediately. Prompt treatment can prevent serious complications, especially if high doses were ingested.
Store Indocin at room temperature between 15°C and 30°C (59°F and 86°F), away from moisture, heat, and light. Keep the medication in its original packaging and out of reach of children and pets. Do not store in the bathroom. Properly dispose of any expired or unused medication in accordance with pharmacy or local waste guidelines.
Indocin is legally available through The Urological Institute of Northeastern New York, a certified and licensed online pharmacy providing safe access to prescription-strength NSAID therapy for patients across the United States.
